Flu Vaccine Example

 

The ability to detect and definitely identify multiple related pathogens can be demonstrated clearly with Influenza Virus Vaccine, which is an inactivated Influenza vaccine comprised of Influenza A and B virus, including subtypes, A/H1N1 and A/H3N2, with the specific strain composition of each subtype varying by flu season.

 

If an area containing Influenza tiles (blue box) is examined, large amounts of strong signal, representing signal from true positive hybridization events, can be seen. Signal is converted into nucleotide sequence as a file using a translation key, and a small region of positive signal (red box) generates 45 bases corresponding to the Influenza A hemagglutinin gene (HA), subtype HA1. Examination of the file output clearly shows long contiguous stretches of called sequence from the Influenza A HA1 gene, but extremely little called sequence, indicated as non calls, from neighboring genes of other respiratory pathogens, such as Enterovirus 70 UTR and Influenza A HA10. If the entire sequence called from the HA1 tile is examined, the identity is revealed as only A/New Caledonia/20/1999, the exact strain that was included in the 2005-2006 vaccine.

 

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